Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation
نویسندگان
چکیده
منابع مشابه
Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.
The checkpoint kinase ATM is centrally involved in the cellular response to DNA double-strand breaks. However, the mechanism of ATM activation during genotoxic stress is only partially understood. Here we report a direct regulatory linkage between the protein serine-threonine phosphatase 5 (PP5) and ATM. PP5 interacts with ATM in a DNA-damage-inducible manner. Reduced expression of PP5 attenuat...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2004
ISSN: 0890-9369
DOI: 10.1101/gad.1176004